Effects of Levodopa on quality of sleep and nocturnal movements in Parkinson’s Disease

To evaluate the effects of Levodopa and specifically the frequently used Levodopa CR on sleep, we first compared subjective rating of sleep quality in a large dataset of n > 1100 patients from three independent PD patient cohorts, allowing to stratify both an exploration cohort and two validation cohorts. Then, we explored the use of mobile health technology to compare effectively occurring movements during sleep with subjective ratings of nocturnal akinesia as well as with overall sleep quality rating, related to Levodopa intake, in one of our cohorts.